Rapid weight loss during the menopause transition is not the same clinical problem as rapid weight loss at 35, and almost nobody in this category prices or staffs as though it were.
Compounded semaglutide starts at $70 a month — the lowest published medication price in this set after Mochi's $60 — under a $99 monthly programme fee, so $169 all-in. The fee covers unlimited messaging with menopause-specialised doctors, wellness check-ins, proactive side-effect monitoring, dose adjustments, long-term planning, and monthly nutrition and exercise support tailored specifically to GLP-1 treatment.
That last item is the one worth paying for. Lean mass loss is the most consequential downside of fast weight loss, and oestrogen decline already accelerates both muscle and bone loss in this population. Nutrition and exercise support built around the drug, rather than bolted on, addresses the actual risk.
Your muscle-protection numbers
Weight lost on a GLP-1 is not all fat. Protein intake and resistance training are the two levers with the best evidence behind them. Set your weight to see the targets.
Daily protein target
120–200 g
Roughly 30 g at each of four eating occasions gets you to the bottom of that range.
Resistance training
2–3 ×/week
Full-body sessions covering legs, push and pull. Loaded movement is the signal that tells your body to keep the muscle.
General nutrition and activity information, not medical advice. Protein targets can be inappropriate in kidney disease and some other conditions — check with your clinician before changing your intake.
The availability problem
Alloy is unavailable in Alabama, Arkansas, California, Nevada, Louisiana, Mississippi and the District of Columbia. California alone removes a very large share of the midlife women this programme is built for, and there is no workaround.
On raw cost, CoreAge Rx at $79 and Mochi at $139 both come in lower. What neither offers is a clinician who treats your menopause status as the context for the prescription rather than a box on the intake form.
What it actually costs per year
Advertised prices in this category are usually medication only. Add the membership back in and the ranking changes. Pick a provider, or enter the quote you were given.
One-month semaglutide rate. Starting at $79/month equivalent requires a 12-month plan ($948 total); confirm payment and renewal terms.
- First month
- $139
- Every month after
- $139
- Total over 12 months
- $1,668
No membership on this plan, so every dollar goes to medication and care.
Figures are the providers' own published prices as of our last review of each. Promotional rates, multi-month prepayment and dose changes can all move these numbers — confirm at checkout.
What compounded semaglutide actually is
Semaglutide is the active ingredient in Ozempic and Wegovy, both FDA-approved products from Novo Nordisk. A compounded version is prepared by a pharmacy rather than manufactured by Novo Nordisk, and it is not an FDA-approved product. FDA has not evaluated it for safety, effectiveness or quality.
That distinction is the single most important thing to understand before buying. The efficacy data you have read about — the 15% average body-weight reduction, the cardiovascular outcomes — comes from trials of the branded product. Those results are routinely used to sell compounded versions that were never in the trials.
Dosing typically starts at 0.25 mg weekly and escalates over several months toward a maintenance dose, which is why dose-dependent pricing matters so much: a plan that looks cheap at the starting dose can cost several times more by the time you reach a therapeutic one.
The common side effects are gastrointestinal — nausea, vomiting, diarrhoea, constipation — and are usually worst in the days after a dose increase. They are the main reason people stop. Slower titration and adequate fibre and fluid intake are the standard mitigations.
Before you buy from anyone
- Get the total monthly cost in writing — medication plus any membership, not the headline figure.
- Ask whether the price changes as your dose increases. This is where most of the money is lost.
- Ask which pharmacy compounds it, and whether it is a 503A or 503B facility.
- Confirm what happens if you stop after one month, and whether there is an auto-rebill.
- Ask whether a refund is available if a provider declines to prescribe.
- Tell the prescriber every medication and supplement you take, including anything bought online.