Judged on what you get for the money, Brello's semaglutide is one of the better-value plans in this market. Judged on how the money is taken, it needs reading twice.
Compounded semaglutide is $133 a month, reduced from $198, with virtual fitness and nutrition classes, a private community, the Brello app and ongoing support included, shipped in two to three days from a USA-based 503A partner pharmacy.
Against the field that is competitive: cheaper than Measured at $168 all-in, Eden at $198 and Ivím at $224, and bundling more than CoreAge Rx does at $99. Fridays at $117 with a $0 membership and no commitment remains the better structural deal for anyone who wants similar extras without locking in.
The conditions attached
The $133 reflects the monthly cost billed as a three-month supply. All plans require a three-month minimum commitment and automatically renew every eleven weeks at the rate charged at checkout until cancelled. Final pricing is stated to vary based on individual treatment plan.
Brello also sells NAD+ at $79, sermorelin at $116 and MICC injections at $66 on the same page, all on the same commitment structure. Our guides to NAD+ and peptide therapy cover what the evidence supports for those.
What it actually costs per year
Advertised prices in this category are usually medication only. Add the membership back in and the ranking changes. Pick a provider, or enter the quote you were given.
One-month semaglutide rate. Starting at $79/month equivalent requires a 12-month plan ($948 total); confirm payment and renewal terms.
- First month
- $139
- Every month after
- $139
- Total over 12 months
- $1,668
No membership on this plan, so every dollar goes to medication and care.
Figures are the providers' own published prices as of our last review of each. Promotional rates, multi-month prepayment and dose changes can all move these numbers — confirm at checkout.
What compounded semaglutide actually is
Semaglutide is the active ingredient in Ozempic and Wegovy, both FDA-approved products from Novo Nordisk. A compounded version is prepared by a pharmacy rather than manufactured by Novo Nordisk, and it is not an FDA-approved product. FDA has not evaluated it for safety, effectiveness or quality.
That distinction is the single most important thing to understand before buying. The efficacy data you have read about — the 15% average body-weight reduction, the cardiovascular outcomes — comes from trials of the branded product. Those results are routinely used to sell compounded versions that were never in the trials.
Dosing typically starts at 0.25 mg weekly and escalates over several months toward a maintenance dose, which is why dose-dependent pricing matters so much: a plan that looks cheap at the starting dose can cost several times more by the time you reach a therapeutic one.
The common side effects are gastrointestinal — nausea, vomiting, diarrhoea, constipation — and are usually worst in the days after a dose increase. They are the main reason people stop. Slower titration and adequate fibre and fluid intake are the standard mitigations.
Before you buy from anyone
- Get the total monthly cost in writing — medication plus any membership, not the headline figure.
- Ask whether the price changes as your dose increases. This is where most of the money is lost.
- Ask which pharmacy compounds it, and whether it is a 503A or 503B facility.
- Confirm what happens if you stop after one month, and whether there is an auto-rebill.
- Ask whether a refund is available if a provider declines to prescribe.
- Tell the prescriber every medication and supplement you take, including anything bought online.