Across every other provider we have reviewed, compounded tirzepatide costs meaningfully more than compounded semaglutide. Amble is the only one that does not price them separately in public.
The gap is real and consistent elsewhere: CoreAge Rx starts at $79 for semaglutide and $129 for tirzepatide, both monthly equivalents on 12-month plans, Eden $99 and $199, Measured $119 and $219, Fridays $117 and $198. Tirzepatide's raw material costs more, and every transparent provider shows it.
Amble advertises plans from $99, a GLP-1 card from $179, and another from $135, with no molecule attached to any of them. The most likely reading is that $99 is a semaglutide starting-dose figure and tirzepatide sits at the top of the range — but that is inference, and you should not buy on inference.
What the terms give you
No membership fees or hidden costs, no insurance required, unlimited 24/7 support, free shipping. Those are genuinely good terms, and if the tirzepatide figure turns out to be $179 all-in with no membership, Amble is competitive with Fridays at $198 and better than Measured at $268.
If it turns out to be higher, you will discover that at checkout rather than here. Ask before you start the quiz.
What it actually costs per year
Advertised prices in this category are usually medication only. Add the membership back in and the ranking changes. Pick a provider, or enter the quote you were given.
One-month semaglutide rate. Starting at $79/month equivalent requires a 12-month plan ($948 total); confirm payment and renewal terms.
- First month
- $139
- Every month after
- $139
- Total over 12 months
- $1,668
No membership on this plan, so every dollar goes to medication and care.
Figures are the providers' own published prices as of our last review of each. Promotional rates, multi-month prepayment and dose changes can all move these numbers — confirm at checkout.
What compounded tirzepatide actually is
Tirzepatide is the active ingredient in Mounjaro and Zepbound, both FDA-approved products from Eli Lilly. Unlike semaglutide, it acts on two receptors — GLP-1 and GIP — which is the basis for the larger average weight reductions seen in its trials. A compounded version is prepared by a pharmacy and is not FDA-approved or FDA-evaluated.
Compounded tirzepatide is consistently more expensive than compounded semaglutide, typically by $50 to $100 a month. That gap is real and reflects the raw material, so a provider pricing them identically is worth a question rather than a celebration.
Dosing usually starts at 2.5 mg weekly and escalates in 2.5 mg steps. As with semaglutide, dose-flat pricing is worth substantially more than a low starting price, because the starting dose is not the dose most people end up on.
Side effects mirror semaglutide's — predominantly gastrointestinal, worst after dose increases — though some patients report tirzepatide is better tolerated at equivalent efficacy. That is an individual matter and not something a telehealth intake form can predict for you.
Before you buy from anyone
- Get the total monthly cost in writing — medication plus any membership, not the headline figure.
- Ask whether the price changes as your dose increases. This is where most of the money is lost.
- Ask which pharmacy compounds it, and whether it is a 503A or 503B facility.
- Confirm what happens if you stop after one month, and whether there is an auto-rebill.
- Ask whether a refund is available if a provider declines to prescribe.
- Tell the prescriber every medication and supplement you take, including anything bought online.